Nature Made^® SAM-e Complete♦ products help support a healthy mood and joint comfort.^† SAM-e also has other vital functions aside from helping to support a healthy mood. One of these other functions is helping to support joint comfort, which may naturally deteriorate with physical activity and age. SAM-e also provides a source of sulfur—an essential component of joint tissue.^†

You should start out with 400 mg of SAM-e every day. If benefits are not achieved within two weeks, you may require a higher level of supplementation. To determine the proper level of supplementation that works for you, gradually increase the number of tablets (maximum 1,600 mg/day) and consult with your doctor until you begin to experience the desired benefits.

Many people report mood improvement in as little as one to two weeks. If after 2 weeks you are not experiencing desired benefits, you may want to try gradually increasing the dose after consulting with your doctor. If you're taking SAM-e for your joints, you may have to wait up to a month to experience results.

SAM-e supplements may be taken on a daily basis. SAM-e can be used daily to benefit mood and support joint health. So you can continue taking SAM-e as long as you are not experiencing any adverse effects and experience results. If you have any concerns or have changes in your medications, please consult your doctor.

Please refer to the expiration date on the bottle.